How does THYMUSKIN® work?

Effectiveness

For more than 30 years, Thymuskin has been successfully used to fight hair loss and to enhance new hair growth. The dermatologic system is suitable for women and men and has no side effects.

Thymuskin has an immunological effect on hair follicles, as is typical for a thymic preparation.

The biologically active agent GKL-02 inhibits various enzymes that play a key role in the loss of hair. Harmful DHT is blocked. This way Thymuskin reduces the dying of hair follicle cells and can often even totally stop it. Thymuskin activates and proliferates the keratinocytes in the hair matrix, the basic substance of each hair. Growth stimulation by various thymic peptides.

Mode of action

Mode of action in hair growth disorders and hair loss

The thymus gland is an important organ of the lymph system. The thymus is particularly significant in the immune system, because it is where the T-lymphocytes recognise foreign substances in the body, such as bacteria or viruses, are formed. Different peptides, so-called thymosins, are isolated from the thymus.

Thymosins are used in medicine to strengthen the immune system

Some of them are used in different clinical pictures mainly to strengthen the immune system or in cancer therapy. The peptides contained in the thymus are also characterized by their property of neutralizing and normalizing disorders of the hair follicle.

Active GKL-02 complex improves the supply of nutrients to the cell during the growth phase

The success of Thymuskin in treating hair loss in both women and men is due to the biological activity of the bovine-free active GKL-02 complex. It improves the supply of nutrients to the cells of the hair root (follicle) during the growth phase (anagen phase). Thus the unique active substance complex supports the formation of new hair cells and strengthens the existing cells. At the same time it lengthens the hair growth phase. The hair follicles which have remained intact are reactivated, new hairs are formed and the growth phase is clearly lengthened.

Tests on human blood cells have demonstrated that Thymuskin stimulates lymphocytes to divide. The effect is dependent on the concentration of the active GKl-02 complex administered. As a further medical study has shown, the stimulation of the proliferation of human lymphocytes is independent of the bodys own messenger substances in the immune system. The growth-stimulating effect on the cells in the hair follicles is connected with this and accordingly takes place directly in the hair roots.

Thymuskin preparations are thus able to reactivate hair growth on bald patches which are no more than 3 years old.

Thymuskin strengthens the immune defences and reduces the dying of follicle cells

Histologically the hair loss (telogen phase) is preceded by an increase in the mast cells. These mast cells on the hair root disappear again after the hair falls out, therefore a major role in the hair loss process is ascribed to these mast cells. This is where Thymuskin intervenes, by suppressing the activation of the serine proteases trypsin and tryptase which are contained in the mast cells and by altering the cell function. Through the inhibition of these enzymes, the telogen phase is slowed down to the greatest possible extent. The Thymuskin products with GKL-02 contain valuable thymic peptides that are produced totally bovine-free. They are a mimicry of the natural total thymic extract. Depending on the preparation, GKL-02 is enhanced with other additives so that systematic, specific effects can be achieved.

100% bovine-free and no side effects in women or men for 30 years

Thus Thymuskin contains no animal substances but thymic peptides, which are a mimicry to the natural substances, of consistent quality and purity. The peptide compounds in Thymuskin penetrate into the hair root and influence the growth of the hair cells. They work similarly in women and men. No side effects have been identified in the various scientific studies and during the almost 30 years in which Thymuskin has successfully been on the market. Thymuskin also contains vegetable proteins and Vitamins B, E and F, which systematically act on human cells, cell cultures and biological substances.

Bovine-free thymic peptides

Thymuskin displays biological activity and empirical effectiveness

In the test system for mitogenic co-stimulation, the GKL-02 active substance complex displays an effectiveness which is several times greater than that of the natural initial product. This makes it possible to incorporate an active GKL-02 complex, which is very expensive to manufacture, into an economical application concentration according to the respective severity of the hair loss.

The empirical effectiveness of Thymuskin in the different forms of hair loss has been confirmed in a number of clinical studies. Its biological effectiveness is dependent on an adequate concentration, the duration of use and the existence of intact hair follicles.

The effectiveness of Thymuskin has been demonstrated amongst other things using the EpiDerm model, which showed that the cells of the test tissue multiplied under the influence of a 10% solution of Thymuskin. The test tissue consisted of keratinocytes, such as those which are also found in the area of the hair root sheath of the hair follicle (keratinocytes, cells which form the skin's horny layer, originate from epidermal stem cells).

Independent Study confirms effect hypothesis

An independent study* has precisely analyzed and determined the cellular process of hair growth: the thymic peptide Thymulin acts as a direct modulator of human hair follicle growth. Thymuskin contains Thymulin, along with other biologically highly active thymic peptides (free of animal ingredients).In the laboratory testing, this thymic peptide led to high growth rates in human hair follicles. It interacts with parts of the neuroendocrine system, and right those hormones are produced, which are involved in the regulation of human hair growth (such as prolactin and thyrotropin). This mechanism of action stimulates also in Thymuskin Shampoo and in Thymuskin Scalp Serum the process of hair formation and thus supports  natural hair growth.

*Meier N et al.: Thymic Peptides Differentially Modulate Human Hair Follicle Growth. Journal of Investigative Dermatology (2012) 132, 1516-1519